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Mouse TARDBP Ready-To-Use IHC Kit (IHC0429M)  
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產品編號 IHC0429M
英文名稱 Mouse TARDBP Ready-To-Use IHC Kit
中文名稱 小鼠Tar DNA 結合蛋白43即用型免疫組化試劑盒
別    名 1190002A23Rik; ALS10; C85084; TARDBP; TDP-43; TDP43; wu:fb77f02; wu:fc52g10  
適用樣品基質 FFPE tissue
保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
產品介紹 TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

SWISS:
Q13148

Gene ID:
23435

產品圖片
Immunohistochemical analysis of paraffin embedded mouse cerebellum tissue slide using IHC0429M (Mouse TARDBP IHC Kit).
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