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Mouse NALP3/CIAS1 Ready-To-Use IHC Kit (IHC0396M)  
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產(chǎn)品編號 IHC0396M
英文名稱 Mouse NALP3/CIAS1 Ready-To-Use IHC Kit
中文名稱 小鼠細胞凋亡誘導蛋白NALP3即用型免疫組化試劑盒
別    名 AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; Mmig1; MWS; NALP3; NLRP3; PYPAF1  
適用樣品基質 FFPE tissue
保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
產(chǎn)品介紹 This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

SWISS:
Q96P20

Gene ID:
114548

產(chǎn)品圖片
Immunohistochemical analysis of paraffin embedded mouse spleen tissue slide using IHC0396M (Mouse NALP3/CIAS1 IHC Kit).
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