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CRYZ Rabbit pAb (bs-14080R)  
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產品編號 bs-14080R
英文名稱 CRYZ Rabbit pAb
中文名稱 晶狀體蛋白ζ抗體
別    名 Crystallin zeta(quinone reductase); Crystallin zeta; Cryz; DKFZp779E0834; FLJ41475; NADPH:quinone reductase; QOR_HUMAN; Quinone oxidoreductase; Zeta crystallin; Zeta-crystallin;  ζ-crystallin.
研究領域 細胞生物  神經生物學  信號轉導  新陳代謝  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 35 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRYZ: 61-160/329 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Function:
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Only very low amounts in the lens.

Similarity:
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

SWISS:
Q08257

Gene ID:
1429

Database links:

Entrez Gene: 1429 Human

Omim: 123691 Human

SwissProt: Q08257 Human

Unigene: 83114 Human



產品圖片
Sample: Lane 1: Human K562 cell lysates Lane 2: Human Jurkat cell lysates Primary: Anti-CRYZ (bs-14080R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa
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